Heart Disease Stroke Risk Factors May Increase In Severity Before Menopause

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African-American Women At Greater Risk For Cardiovascular Disease, Diabetes Than White Women.

The severity of key risk factors for heart disease, diabetes and stroke appears to increase more rapidly in the years leading up to menopause, rather than after. New research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

The risk factors, together known as metabolic syndrome, include a large waistline, high triglyceride (a blood fat) levels, low HDL (the “good” cholesterol) levels, high blood pressure and high blood sugar when fasting. Paying attention to food quality and what’s in the processed foods being consumed is a good first step to avoiding some of these risk factors. There’s lot’s of evidence pointing to food as highly effective medicine for reducing risk..Eat it to stay well. Or take prescription drugs along with their known side effects. Leaching nutrients leading to malnutrition pose significant risks. Eat your way out of heart disease and stroke risk.
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Full bibliographic information Progression of Metabolic Syndrome Severity during the Menopausal Transition
Co-authors are Matthew J. Gurka, Ph.D.; Abhishek Vishnu, Ph.D.; and Richard A. Santen, M.D.
Journal of the American Heart Association
(Manuscript number: JAHA/2016/003609R1)

http://newsroom.heart.org/news/heart-disease-stroke-risk-factors-may-increase-in-severity-before-menopause?preview=bbe6b80d65da82a56ff05c00af0e6cd4

Vitamin B Reduces Stroke Incidence

Vitamin B Supplementation, Homocysteine Levels, and

the Risk of Cerebrovascular Disease

 

Foods Rich In Vitamin B-12A meta-analysis published in Neurology indicates that Vitamin B supplementation to lower homocysteine levels significantly reduces the incidence of stroke events.

Objective: To perform a meta-analysis on the effect of lowering homocysteine levels via B vitamin supplementation on cerebrovascular disease risk.

Methods: Using clinical trials published before August 2012 to assess stroke events, we used relative risks (RRs) with 95% confidence intervals (95% CIs) to measure the association between B vitamin supplementation and endpoint events using a fixed-effects model and χ2 tests. We included 14 randomized controlled trials with 54,913 participants in this analysis.

Results: We observed a reduction in overall stroke events resulting from reduction in homocysteine levels following B vitamin supplementation (RR 0.93; 95% CI 0.86–1.00; p = 0.04) but not in subgroups divided according to primary or secondary prevention measures, ischemic vs hemorrhagic stroke, or occurrence of fatal stroke.

There were beneficial effects in reducing stroke events in subgroups with ≥3 years follow-up time, and without background of cereal folate fortification or chronic kidney disease (CKD). Some trials that included CKD patients reported decreased glomerular filtration rate with B vitamin supplementation.

We conducted detailed subgroup analyses for cyanocobalamin (vitamin B12) but did not find a significant benefit regarding intervention dose of vitamin B12 or baseline blood B12 concentration.

Stratified analysis for blood pressure and baseline participant medication use showed benefits with >130 mm Hg systolic blood pressure and lower antiplatelet drug use in reducing stroke risk.

Conclusions: B vitamin supplementation for homocysteine reduction significantly reduced stroke events, especially in subjects with certain characteristics who received appropriate intervention measures.

http://www.neurology.org/content/early/2013/09/18/WNL.0b013e3182a823cc.short

  1. Yuan Gao, MD

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