Caffeine Against Alzheimer’s Disease

 

Caffeine Has Positive Effect On Tau Deposits In Alzheimer’s

As part of a German-French research project, a team led by  Dr. Christa E. Müller from the University of Bonn and Dr. David Blum from the University of Lille was able to demonstrate for the first time that caffeine has a positive effect on tau deposits in Alzheimer’s disease. The two-years project was supported with 30,000 Euro from the non-profit Alzheimer Forschung Initiative e.V. (AFI) and with 50,000 Euro from the French Partner organization LECMA. The initial results were published in the online edition of the journal “Neurobiology of Aging.”

Tau deposits, along with beta-amyloid plaques, are among the characteristic features of Alzheimer’s disease. These protein deposits disrupt the communication of the nerve cells in the brain and contribute to their degeneration. Despite intensive research there is no drug available to date  which can prevent this detrimental process. Based on  the results of Prof. Dr. Christa Müller from the University of Bonn, Dr. David Blum and their team, a new class of drugs may now be developed for the treatment of Alzheimer’s disease.

Caffeine, an adenosine receptor antagonist, blocks various receptors in the brain which are activated by adenosine. Initial results of the team of researchers had already indicated that the blockade of the adenosine receptor subtype A2A in particular could play an important role. Initially, Prof. Müller and her colleagues developed an A2A antagonist in ultrapure and water-soluble form (designated MSX-3). This compound had fewer adverse effects than caffeine since it only blocks only the A2A adenosine receptor subtype, and at the same time it is significantly more effective. Over several weeks, the researchers then treated genetically altered mice with the A2A antagonist. The mice had an altered tau protein which, without therapy, leads to the early development of Alzheimer’s symptoms.

In comparison to a control group which only received a placebo, the treated animals achieved significantly better results on memory tests. The A2A antagonist displayed positive effects in particular on spatial memory. Also, an amelioration of the pathogenic processes was demonstrated in the hippocampus, which is the site of memory in rodents.

“We have taken a good step forward,” says Prof. Müller. “The results of the study are truly promising, since we were able to show for the first time that A2A adenosine receptor antagonists actually have very positive effects in an animal model simulating hallmark characteristics and progression of  the disease. And the adverse effects are minor.”

The researchers now want to test the A2A antagonist in additional animal models. If the results are positive, a clinical study may follow. “Patience is required until A2A adenosine receptor antagonists are approved as new therapeutic agents for Alzheimer’s disease. But I am optimistic that clinical studies will be performed,” says Prof. Müller.

Attached files

  • Characteristic of Alzheimer’s disease: The tau protein. (c) Photo: Alzheimer Forschung Initiative e.V.

 

→  Read full article

 

Hemp Revolution Research Case Underway

Nutrition News Hemp Revolution Cover

Hemp Revolution Is Well Underway

Ongoing research into the complex compounds found in cannabis are adding to the knowledge base  Dr. Daniele Piomelli offers testimony on Medical Cannabis

Dr. Daniele Piomelli, Editor-in-Chief of Cannabis and Cannabinoid Research, provided testimony on the science behind Cannabis research at a Senate Judiciary Committee, and Subcommittee on Crime and Terrorism, hearing on “Researching the Potential Medical Benefits and Risks of Marijuana.”

The hearing was held on July 13, 2016, and was a timely discussion about researching the potential medical benefits of the Cannabis plant and its cannabinoid chemical components.Testimony was offered to the Subcommittee on Crime and Terrorism. I think that says it all when it comes to the dogged reluctance to putting the research we already have into wide spread medical use.

The hearing also addressed further removal of unnecessary barriers to research on cannabis and cannabinoids; especially, cannabidiol in the United States, where we like to think of ourselves as exceptional. An in the case of adopting medicinal cannabis, we are exceptionally resistant to health and wellness.

 

Evidence Of Reefer Madness From The Stone Age

Nutrition News Cannabis Leaves
Nutrition News Hemp Issue

Founders of Western civilization were prehistoric dope dealers

DAILY NEWS  7 July 2016

It looks like the use of the cannabis plant is part of the march of civilization. A review of the data on cannabis in archaeology, links an intensification of cannabis use in East Asia with the rise of transcontinental trade at the dawn of the Bronze Age, some 5000 years ago.

That wonder weed cannabis keeps showing up in the story of who we are. People who understand how to take advantage of nature’s bounty. Medical and industrial researchers are both deep into the weeds, pun intended, with niche research applications for this plant.

Cannabis entered the archaeological record of Japan and Eastern Europe at almost exactly the same time, between about 11,500 and 10,200 years ago. A review of archaeological data links an intensification of cannabis use in East Asia with the rise of transcontinental trade at the dawn of the Bronze Age, some 5000 years ago.

That’s a long time to be keeping track of humanity”s use of a “Class 1 drug” under the U.S. Controlled Substance Act (CSA). Maybe our ancestors were on to something after.

Read full article

Magnesium Lowers Blood Pressure

Magnesium Lowers Blood Pressure

Magnesium may modestly lower blood pressure

06 July 2016 American Heart Association

Researchers have long debated whether magnesium plays a role in regulating blood pressure with inconsistent and controversial evidence from studies in humans. This meta-analysis, however, collected data from 34 clinical trials, involving 2,028 participants, and found a small but significant association between magnesium intake and reduced blood pressure.

With epic levels of obesity and CVD, it’s only a matter of time before we start looking at nutritional supplementation as an accessible, affordable and effective path to health and wellness.
→  Read full article

Full bibliographic information: Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials (DOI: 10.1161/HYPERTENSIONAHA.116.07664.)

The Glycaemic Outcomes Of Cinnamon

Cinnamon Stick and Powder

The Glycaemic Outcomes Of Cinnamon, A Review Of The Experimental Evidence And Clinical Trials

Arjuna B. Medagama Email author Nutrition Journal201514:108 DOI: 10.1186/s12937-015-0098-9 ©  Medagama. 2015

Recent estimates show that over 80 % of people living in developing countries depend on Complimentary Alternative Medicine for treatment of health conditions [9]. In the United States an increase of 380 % is seen in the use of herbal remedies [13]. The economic burden of CAMs is substantial, with the UK population in 2001 having spent an estimated 340 million pounds on CAMs [14]. More recently in 2013, Herman estimates the cost of Complementary and Integrative Medicine (CIM) in the US to be 34 billion dollars [15].

Integrative medicine is a new discipline of medicine that combines conventional medicine with evidence-based complementary medicines. Patients with diabetes are increasingly eager to be part of their disease management and keen to try out integrative strategies that involve lifestyle changes and self management [16].

Food as medicine is still the quickest direct route to wellness. Now we’re just going to prove it to ourselves all over again.

→  Read full article

Superfoods cover image

Play The Is It Healthy Game!

Read Nutrition News

Making Healthy Choices Easier Than You Think

You have Successfully Subscribed!