Vitamin C Effective In Targeting Cancer Stem Cells

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“Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step.”

 

Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

 

“Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.”

 

Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK.

08 March 2017 Salford, The University of

Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug.

Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK.

The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours.

Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: “We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C.

“Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step.”

Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

The Salford team set out to assess the bioenergetics of cancer stem cells – the processes which allow the cells to live and thrive – with a view to disrupting their metabolism.

Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products  – caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid – and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency.

Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25% on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context, it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the “powerhouse” of the cell.

Dr Gloria Bonuccelli, lead author and another member of the Salford team added: “This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer.

“Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.”

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=15400

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Hemp Revolution Research Case Underway

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Hemp Revolution Is Well Underway

Ongoing research into the complex compounds found in cannabis are adding to the knowledge base  Dr. Daniele Piomelli offers testimony on Medical Cannabis

Dr. Daniele Piomelli, Editor-in-Chief of Cannabis and Cannabinoid Research, provided testimony on the science behind Cannabis research at a Senate Judiciary Committee, and Subcommittee on Crime and Terrorism, hearing on “Researching the Potential Medical Benefits and Risks of Marijuana.”

The hearing was held on July 13, 2016, and was a timely discussion about researching the potential medical benefits of the Cannabis plant and its cannabinoid chemical components.Testimony was offered to the Subcommittee on Crime and Terrorism. I think that says it all when it comes to the dogged reluctance to putting the research we already have into wide spread medical use.

The hearing also addressed further removal of unnecessary barriers to research on cannabis and cannabinoids; especially, cannabidiol in the United States, where we like to think of ourselves as exceptional. An in the case of adopting medicinal cannabis, we are exceptionally resistant to health and wellness.

 

Evidence Of Reefer Madness From The Stone Age

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Founders of Western civilization were prehistoric dope dealers

DAILY NEWS  7 July 2016

It looks like the use of the cannabis plant is part of the march of civilization. A review of the data on cannabis in archaeology, links an intensification of cannabis use in East Asia with the rise of transcontinental trade at the dawn of the Bronze Age, some 5000 years ago.

That wonder weed cannabis keeps showing up in the story of who we are. People who understand how to take advantage of nature’s bounty. Medical and industrial researchers are both deep into the weeds, pun intended, with niche research applications for this plant.

Cannabis entered the archaeological record of Japan and Eastern Europe at almost exactly the same time, between about 11,500 and 10,200 years ago. A review of archaeological data links an intensification of cannabis use in East Asia with the rise of transcontinental trade at the dawn of the Bronze Age, some 5000 years ago.

That’s a long time to be keeping track of humanity”s use of a “Class 1 drug” under the U.S. Controlled Substance Act (CSA). Maybe our ancestors were on to something after.

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Magnesium Lowers Blood Pressure

Magnesium Lowers Blood Pressure

Magnesium may modestly lower blood pressure

06 July 2016 American Heart Association

Researchers have long debated whether magnesium plays a role in regulating blood pressure with inconsistent and controversial evidence from studies in humans. This meta-analysis, however, collected data from 34 clinical trials, involving 2,028 participants, and found a small but significant association between magnesium intake and reduced blood pressure.

With epic levels of obesity and CVD, it’s only a matter of time before we start looking at nutritional supplementation as an accessible, affordable and effective path to health and wellness.
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Full bibliographic information: Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials (DOI: 10.1161/HYPERTENSIONAHA.116.07664.)

Key House Panel Directs USDA to Consider Funding Multivitamins for Use in WIC Program

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Nutrition News Change What You Kids Eat and Change Their Future

Key House Panel Directs USDA to Consider Funding Multivitamins for Use in WIC Program

A key House Panel directed the U.S. Department of Agriculture’s (USDA) Food Nutrition Services (FNS) to prepare a report assessing the benefits of allowing vitamins to be purchased through the supplemental nutrition program for women, infants and children (WIC).

“Women, infants and children utilizing the WIC program deserve equal access to and should be allowed to purchase vitamins,” said Dan Fabricant, CEO and executive director of NPA (Natural Products Association).  “The Committee’s instructions are a step in the right direction towards addressing the crisis of undernourishment in America.”

Vitamins are proven to have many health benefits especially relevant to those the WIC program intends to help:
· Classic nutrient deficiency diseases (scurvy, pellagra, and iron deficiency anemia);

· Improve appetite and growth rates in low-income children;

· Prevent neural tube birth defects;

· Protect against heart disease and stroke; and

· Build bone mass in the young.

“We will continue to look for policy options to improve access and availability to products that support a healthy lifestyle for American consumers,” Fabricant said.

NPA also sent a letter to the chairman and ranking member of the House Committee on Appropriations expressing its strong view that the WIC program should be expanded to include the purchase of multivitamins and multiminerals.

Read more www.npainfo.org.

 

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