Carb-Restricted Diet Battles Fatty Liver Disease

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The researchers found that the metabolism of dangerous hepatic lipids was “strongly linked” to rapid increases in B vitamins and the bacteria that produce folic acid.

New details about how a carbohydrate-restricted diet improves metabolism were revealed in a study published today. This could lead to improved treatments for non-alcoholic fatty liver disease (NAFLD).

15/02/2018 KTH The Royal Institute of Technology

A research team in Sweden examined  the effects of reduced carbohydrate consumption – without an accompanying reduction in calorie intake – by putting 10 subjects with obesity and high liver fat on a two-week diet. The study, which involved KTH Royal Institute of Technology’s SciLifeLab research center, combined clinical and big data analysis to determine the subsequent changes in metabolism and gut bacteria.

By doing so, they identified why the subjects showed “rapid and dramatic” reductions of liver fat and other cardiometabolic risk factors, along with marked decreases in synthesis of hepatic fat. Published today in Cell Metabolism, the work was authored by researchers from KTH, University of Gothenburg and other international collaborators.

Adil Mardinoglu, a systems biology researcher at KTH, says that the subjects were restricted to an isocaloric, low-carbohydrate diet with increased protein content. The researchers found that the metabolism of dangerous hepatic lipids was “strongly linked” to rapid increases in B vitamins and the bacteria that produce folic acid.

This benefit was coupled by a reduction in the expression of genes that are involved in fatty acid synthesis, and an increase in the expression of genes involved in folate-mediated one-carbon metabolism and fatty acid oxidation.

“A carbohydrate-restricted dietary intervention such as the one we used can be an efficient treatment strategy for a severe health problem, as medical science continues the development of new drugs,” Mardinoglu says.

The study relied upon a combination of systems medicine and advanced clinical studies, with close interaction between experts in systems medicine, basic scientists, nutritionists and clinicians. Combining forces enabled the team to apply a “multi-omics” approach, which means integrating multiple data sets from the body’s omes (genome, proteome, transcriptome, etc.) to identify biomarkers.

“We’ve moved from an era where scientists could work individually and command – in one laboratory – everything they needed, to a world that’s much more interactive,” Mardinoglu says.

Lead author Jan Boren, a professor at University of Gothenburg, says: “We found that the diet, independently of weight-loss, induced rapid and dramatic reductions of liver fat and other cardiometabolic risk factors, and revealed hitherto unknown underlying molecular mechanisms.

“It’s important, however, to clarify that diets are complicated and that one type of diet does not fit everyone. For example, subjects with hypercholesterolemia should be careful.”
Liver fat is the earliest abnormality in the pathogenesis of both NAFLD and alcoholic fatty liver disease (AFLD) due to metabolic risk factors associated with insulin resistance and metabolic syndrome in the presence or absence of alcohol consumption.

Therefore, the strategies the research team identified could be used also for the treatment of AFLD patients, Boren says.

Full bibliographic information

Mardinoglu et al.,

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans,

Cell Metabolism (2018)

https://doi.org/10.1016/j.cmet.2018.01.005

Carb-Restricted Diet Battles Fatty Liver Disease

Tart Cherry Juice Lowers Blood Pressure

The metabolism of dangerous hepatic lipids was “strongly linked” to rapid increases in B vitamins and the bacteria that produce folic acid.

 “We found that the diet, independently of weight-loss, induced rapid and dramatic reductions of liver fat and other cardiometabolic risk factors, and revealed hitherto unknown underlying molecular mechanisms.”

Tart Cherry Juice Lowers Blood Pressure

Study Shows How A Carb-restricted Diet Battles Fatty Liver Disease

KTH The Royal Institute of Technology

New details about how a carbohydrate-restricted diet improves metabolism were revealed in a study published today, which could lead to improved treatments for non-alcoholic fatty liver disease (NAFLD).

A research team in Sweden examined  the effects of reduced carbohydrate consumption – without an accompanying reduction in calorie intake – by putting 10 subjects with obesity and high liver fat on a two-week diet. The study, which involved KTH Royal Institute of Technology’s SciLifeLab research center, combined clinical and big data analysis to determine the subsequent changes in metabolism and gut bacteria.

By doing so, they identified why the subjects showed “rapid and dramatic” reductions of liver fat and other cardiometabolic risk factors, along with marked decreases in synthesis of hepatic fat. Published today in Cell Metabolism, the work was authored by researchers from KTH, University of Gothenburg and other international collaborators.

Adil Mardinoglu, a systems biology researcher at KTH, says that the subjects were restricted to an isocaloric, low-carbohydrate diet with increased protein content. The researchers found that the metabolism of dangerous hepatic lipids was “strongly linked” to rapid increases in B vitamins and the bacteria that produce folic acid.

This benefit was coupled by a reduction in the expression of genes that are involved in fatty acid synthesis, and an increase in the expression of genes involved in folate-mediated one-carbon metabolism and fatty acid oxidation.

“A carbohydrate-restricted dietary intervention such as the one we used can be an efficient treatment strategy for a severe health problem, as medical science continues the development of new drugs,” Mardinoglu says.

The study relied upon a combination of systems medicine and advanced clinical studies, with close interaction between experts in systems medicine, basic scientists, nutritionists and clinicians. Combining forces enabled the team to apply a “multi-omics” approach, which means integrating multiple data sets from the body’s omes (genome, proteome, transcriptome, etc.) to identify biomarkers.

“We’ve moved from an era where scientists could work individually and command – in one laboratory – everything they needed, to a world that’s much more interactive,” Mardinoglu says.

Lead author Jan Boren, a professor at University of Gothenburg, says: “We found that the diet, independently of weight-loss, induced rapid and dramatic reductions of liver fat and other cardiometabolic risk factors, and revealed hitherto unknown underlying molecular mechanisms.

“It’s important, however, to clarify that diets are complicated and that one type of diet does not fit everyone. For example, subjects with hypercholesterolemia should be careful.”

Liver fat is the earliest abnormality in the pathogenesis of both NAFLD and alcoholic fatty liver disease (AFLD) due to metabolic risk factors associated with insulin resistance and metabolic syndrome in the presence or absence of alcohol consumption.

Therefore, the strategies the research team identified could be used also for the treatment of AFLD patients, Boren says.

https://doi.org/10.1016/j.cmet.2018.01.005

 

Burn Calories Fast With These 6 Foods

Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure

Want to burn your calories fast? Just add these 6 foods to diet to speed up metabolism

International Business Times

Take a look at some of these nutrient-rich foods to increase your metabolism.

There are a number of drinks and other products in the market that claim to boost your metabolism. But the effectiveness of these products is, however, questionable. What goes without saying is that natural foods are the best. If you didn’t know, these vitamins and nutrient rich foods can actually boost your metabolism and give your body the sustenance it needs to survive and thrive.

Beans

Beans are loaded with dietary fibre which lowers the insulin levels and improves insulin sensitivity over time. This in turn, helps your body to store less fat. It serves as an excellent food for boosting metabolism.

Oily fish

Oily fishes such as salmon and tuna are rich in omega-3 fatty acids. These fatty acids reduce resistance to leptin – a hormone that helps in determining how fast fat is burned.

It also balances blood sugar and helps in reducing inflammation and both of them helps in regulating metabolism. So, oily fish is a great choice for boosting your metabolism.

Cruciferous vegetables

Cruciferous vegetables such as cabbage, broccoli, cauliflower, and Brussels sprouts contain essential nutrients like calcium and vitamin C that will speed up your metabolism. Apart from it, they also have high water and fibre content. This combination increases the ability of the body to burn fat.

Hot peppers

You may have heard that spicy foods help in boosting your metabolism and it is true. The compound, capsaicin that makes peppers hot helps your body burn more energy. It even curbs your hunger for at least three hours after you eat. It serves as an excellent food for increasing metabolism.

Berries

Berries stabilize the glucose levels and decrease the body fat content showing beneficial effects on metabolism. Eating red berries also hasa positive impact on cardiovascular health.

Citrus fruits

Citrus fruits are great for digestion. They are low in sugar and contain an antioxidant that helps in lower your blood sugar response after meals. The vitamin C in citrus fruits helps in faster metabolism.

→  Read full article

 

Exercise Causes Epigenetic Changes To Fat Cells

fat cell dna map
Woman Wearing Oversized Jeans
fat cell dna map

A Comprehensive Map of AncestryDNA Ethnicity Regions

Altered DNA methylation as a result of physical activity could be one of the mechanisms of how these genes affect the risk of disease.

 

Exercise, even in small doses, changes the expression of our innate DNA. New research from Lund University in Sweden has described for the first time what happens on an epigenetic level in fat cells when we undertake physical activity.

“Our study shows the positive effects of exercise, because the epigenetic pattern of genes that affect fat storage in the body changes”, says Charlotte Ling, Associate Professor at Lund University Diabetes Centre.

The cells of the body contain DNA, which contains genes. We inherit our genes and they cannot be changed. The genes, however, have ‘methyl groups’ attached which affect what is known as ‘gene expression’ – whether the genes are activated or deactivated. The methyl groups can be influenced in various ways, through exercise, diet and lifestyle, in a process known as ‘DNA methylation’. This is epigenetics, a relatively new research field that in recent years has attracted more and more attention.

In the study, the researchers investigated what happened to the methyl groups in the fat cells of 23 slightly overweight, healthy men aged around 35 who had not previously engaged in any physical activity, when they regularly attended spinning and aerobics classes over a six-month period.

“They were supposed to attend three sessions a week, but they went on average 1.8 times”, says Tina Rönn, Associate Researcher at Lund University.

Using technology that analyses 480,000 positions throughout the genome, they could see that epigenetic changes had taken place in 7,000 genes (an individual has 20–25 000 genes). They then went on to look specifically at the methylation in genes linked to type 2 diabetes and obesity.

“We found changes in those genes too, which suggests that altered DNA methylation as a result of physical activity could be one of the mechanisms of how these genes affect the risk of disease”, says Tina Rönn, adding that this has never before been studied in fat cells and that they now have a map of the DNA methylome in fat.

In the laboratory, the researchers were able to confirm the findings in vitro (studying cell cultures in test tubes) by deactivating certain genes and thus reducing their expression. This resulted in changes in fat storage in fat cells.

 

Food Pyramid Built On Shaky Ground

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Tart Cherry Juice Lowers Blood Pressure

Recommendations Not Based On Clinical Data

The latest issue of Nutrition News contains an interview with Ann Louise Gittleman, the first lady of nutrition. She was the one calling a flag on the play back in the 80’s when we were being told that fat is dangerous. “Eat Fat, Lose Weight” breaks down the skinny on fats.

Steven E Nissen and Nina Tiecholz have an interesting article discussing the back story of the food pyramid scheme that seems to change based on a ring-around-the-posey strategy where grains, fats or carbs is left out.

Despite reams of clinical data on nutrition, our recommended daily doses are laughable for most nutrients. What we get through fortified foods is like trying to bail out a life boat with a thimble.

The food pyramid scheme is one more swing at raising consumer awareness about basic human nutritional health requirements.

It’s in our best interest to understand how nutrition science can impact the ‘owners manual’ for our own bodies.

 

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