Harnessing Gut Bacteria For Human Health

Bugs as Drugs: Harnessing Novel Gut Bacteria for Human Health

03/05/2016 10:33 GMT  Wellcome Trust Sanger Institute

Scientists at the Wellcome Trust Sanger Institute have grown and catalogued more than 130 bacteria from the human intestine.

Imbalances in our gut microbiome can contribute to complex conditions and diseases such as obesity, Inflammatory Bowel Disease, Irritable Bowel Syndrome and allergies.

Published in Nature, this research will enable scientists to understand how our bacterial ‘microbiome’ helps keep us healthy and start to create tailor-made treatments with specific beneficial bacteria.

→  Read full article

Full bibliographic information

Hilary P. Browne et al. (2016). Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature. DOI: 10.1038/nature17645

 

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Studies Show Vaccinated Kids Sicker Than Unvaccinated

Vaccination Stats

Childhood vaccination programs now includes forty-eight doses of vaccines for fourteen diseases

— all administered between birth and age six

— compared to three vaccinations for seven diseases in the 1970s.

 Vaccinated children were more than three times as likely to have allergies, six times as likely to have pneumonia, about three times as likely to have NDD, and almost twice as likely to have any chronic illness.

Preterm birth combined with vaccination was associated with nearly seven-fold increased odds of neurological development disorders.

BY  ON 

The first study, comparing unvaccinated and vaccinated children, looked at the link between preterm (i.e., premature) infants, vaccination, and the development of neurological development disorders (NDD) such as autism spectrum disorder, ADHD, and learning disabilities. Preterm babies are already at increased risk for NDD, but the study found that vaccinating preterm babies—which is standard medical practice—significantly increases that risk. Preterm birth combined with vaccination was associated with nearly seven-fold increased odds of NDD.Two recent studies underscore concerns that science has been abandoned in order to promote Big Pharma’s pro-vaccine agenda. Action Alert!

That’s not all. The second study, which surveyed more than 400 homeschooling mothers with 666 children (39% of whom were unvaccinated), found even more causes for concern. It found that vaccinated kids were, on the whole, sicker than unvaccinated kids. Vaccinated children were more than three times as likely to have allergies, six times as likely to have pneumonia, about three times as likely to have NDD, and almost twice as likely to have any chronic illness.

Additionally, the study also found that vaccinated kids were far more likely to use medications and other health services. They were more likely to have been prescribed antibiotics, allergy drugs, and fever medications; fitted with ventilation ear tubes; visited a doctor in the previous year for a health issue; and been hospitalized. Readers can consult the study for the specific numbers, but we can extrapolate that the healthcare costs of vaccinated children are at least twice that of unvaccinated children—not counting the real costs of caring for children with NDD and chronically sick children for a lifetime.

Like any study, these papers have limitations. The sample size (666 children) is relatively small, and self-reporting surveys can be unreliable. These findings indicate that larger studies comparing the health outcomes of vaccinated and unvaccinated kids should be done.

As the authors note, this is not a radical view: the National Academy of Medicine (formerly the Institute of Medicine), which advises the federal government on health issues, has recommended further study of vaccines. The Academy specifically recommends focusing on the health outcomes of both vaccinated and unvaccinated children, the long-term cumulative effects of vaccines, the timing of vaccinations in relation to the child’s age, the total number of vaccines given, the total number of vaccines given at one time, and the effect of vaccine adjuvants.

It is shocking that such studies have never been done, considering that the childhood vaccination program now includes forty-eight doses of vaccines for fourteen diseases—all administered between birth and age six—compared to three vaccinations for seven diseases in the 1970s. If those who wish to force vaccinations on the US population are so confident that vaccines are safe, why not do the studies?

The likely answer: Big Pharma makes Big Money from pumping the most vulnerable among us full of vaccines.

Science is about examining all the currently available evidence dispassionately before reaching a conclusion—and that conclusion is always open to further evidence or analysis. Sadly, those claiming the mantle of “science” in the vaccine debate are actually rejecting science.

The question is not just whether we vaccinate, but rather how and when we do so. The biggest questions concern the use of adjuvants such as aluminum, which we are injecting right into our bodies where the liver cannot protect us; the use of preservatives; and the appropriateness of the schedule of shots. We need an honest, fact-based discussion of these topics.

Action Alert! Write to the FDA and tell them that they must study the long term effects of vaccination. Please send your message immediately!

Editor’s note (5/9/2017):Within hours of publishing this article, we learned of reports that the Journal of Translational Science has retracted these studies. We will keep you updated as we work to confirm these reports and discern the reason for the retraction. It wouldn’t surprise us if special interests are behind this, since industry has used its clout to exert pressure on scientific journals in the past. 

Update (5/18/2017): We can now confirm that the studies have not been retracted, and are back online.

Quail Eggs An Allergy Relief Nutraceutical

Quail Eggs A Nutraceutical for Allergy Relief
Quail Eggs A Nutraceutical for Allergy Relief

A promising new allergy treatment from Europe is derived from of all things, quail egg powder.

The story of quail eggs begins with a French doctor who noticed that farmers who raised quail had fewer allergy symptoms than other patients from the surrounding area. That launched a series of experiments and clinical trials leading to a product that has shown significant reduction of allergic rhinitis.

Gene Bruno has a detailed, well researched story about quail egg powder at Vitamin Retailer magazine. See references tab.

References:

1 Pawankar R, Canonica GW, Holgate ST, Lockey RF. WAO White Book on Allergy. Milwaukee, WI: World Allergy Organization; 2011.

2 Schiller JS, Lucas JW, Ward BW, Peregoy JA. Summary health statistics for U.S. adults: National Health Interview Survey, 2010. National Center for Health Statistics. Vital Health Stat. 2012;10(252):208 pgs.

3 American College of Allergy, Asthma, and Immunology. Asthma Facts. Retrieved January 22, 2016 from www.aaaai.org/about-the-aaaai/newsroom/asthma-statistics.aspx.

4 Federal Interagency Forum on Child and Family Statistics. America’s Children in Brief: Key National Indicators of Well-Being, 2012. Washington, DC: U.S. Government Printing Office. Retrieved January 22, 2016 from www.childstats.gov/pdf/ac2012/ ac_12.pdf.

5 American College of Allergy, Asthma, and Immunology. Allergy Facts. Retrieved January 22, 2016 from http://acaai.org/news/facts-statistics/allergies. 6 Allergy Treatment: Allergy Medication. American College of Allergy, Asthma & Immunology. 2014. Retrieved January 22, 2016 from http://acaai.org/allergies/treatment/medication.

7 Truffier JC. Approche therapeutique de la maladie allergique par ingestion d’oeufs de caille. La Clinique. 1978;22: 2-4.

8 Bruttman G. Study 1 (réf. 82-83-1): Dust Mite-Induced Allergic Asthma In Children. & Bruttman G. “Ovix” Quail Egg Homogenate: A Clinical Evaluation. La Medicina Biologica. April-June 1995;2:25-29.

9 Bruttman G. Study 2 (réf. 83-2): Exclusive Pollen-Induced Rhinitis. & Bruttman G. “Ovix” Quail Egg Homogenate: A Clinical Evaluation. La Medicina Biologica. April-June 1995;2:25-29.

10 Bruttman G. Study 3 (réf. 83-3): Pollen-Induced Rhinitis. & Bruttman G. “Ovix” Quail Egg Homogenate: A Clinical Evaluation. La Medicina Biologica. April-June 1995;2:25-29.

11 Bruttman G. Study 4 (réf. 88-1): Pollen-Induced Allergic Rhinitis. & Bruttman G. “Ovix” Quail Egg Homogenate: A Clinical Evaluation. La Medicina Biologica. April-June 1995;2:25-29.

12 Benichou AC, Armanet M, Bussiere A, Chevreau N, Cardot J-M, Tetard J. A Proprietary Blend of Quail Egg for the Attenuation of Nasal Provocation with a Standardized Allergenic Challenge: A randomized, double-blind, placebo-controlled study. Food Sci Nutr. 2014 Nov;2(6):655-63.

13 Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63 Suppl 86:8-160.

14 Reed CE, Kita H. The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol. 2004 Nov;114(5):997-1008.

15 Pawankar R, Canonica GW, Holgate ST, Lockey RF. WAO White Book on Allergy. Milwaukee, WI: World Allergy Organization; 2011.

16 Widmer F, Hayes PJ, Whittaker RG, Kumar RK. Substrate preference profiles of proteases released by allergenic pollens. Clin Exp Allergy. 2000 Apr;30(4):571-6.

17 Feeney RE, Means GE, Bigler JC. Inhibition of human trypsin, plasmin, and thrombin by naturally occurring inhibitors of proteolytic enzymes. J Biol Chem. 1969;244(8):1957-1960.

18 Takahashi K, Kitao S, Tashiro M, Asao T, Kanamori M. Inhibitory specificity against various trypsins and stability of ovomucoid from Japanese quail egg white. J Nutr Sci Vitaminol (Tokyo). dec 1994;40(6):593-601.

How Your Gut Microbiota Affects Intestinal Integrity

ProbioticsBacteria in the gut help the body to digest food, and stimulate the immune system. A PhD project at the National Food Institute, Technical University of Denmark, examines whether modulations of the gut bacterial composition affect intestinal integrity, i.e. the ability of the body to maintain a well-regulated barrier function that hinders bacteria from entering the body unintentionally.

The human gut contains more than 100 trillion bacteria, which help the body digest food, produce vitamins protect against disease-provoking bacteria in food, and stimulate the immune system.

All these bacteria are separated from the rest of the body by the intestinal wall, which functions as a selective barrier aimed at allowing only useful substances to pass and be absorbed in the body.

Ellen Gerd Christensen, PhD student at the National Food Institute, has examined whether a change in gut bacterial composition affects intestinal integrity. Results show that increased intake of whole-grain wheat increases the number of bifidobacteria, which are considered beneficial for human health. In addition, the study indicated that bifidobacteria may have a negative effect on intestinal integrity. However, subsequent animal testing in rats showed no changes in intestinal integrity after dosing with live bifidobacteria.

Antibiotics also have an effect
In addition, experiments in rats showed that administration of antibiotics, which cause immense changes in the bacterial gut composition, have an effect on intestinal integrity in either a positive or negative direction, depending on the specific antibiotics.

The findings of this PhD project can be used to clarify how changes in the composition of the natural gut bacterial community may affect intestinal function and permeability.

Read more
Read Ellen Gerd Christensen’s PhD thesis: http://www.food.dtu.dk/english/~/media/Institutter/Foedevareinstituttet/Publikationer/Pub-2014/PhD%20thesis%20Ellen%20Gerd%20Christensen.ashx.

http://www.food.dtu.dk/english/News/Nyhed?id=F1D16D54-1058-4152-8CE7-C573D582DB57

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