– Author Affiliations
Departments of Pediatrics (M.L.O., J.D.O., P.C.W., M.R.H.) and Internal Medicine (N.M.M.), University of Texas Southwestern Medical Center, Dallas, Texas
- Address correspondence to Michele R. Hutchison, M.D., Ph.D., University of Texas Southwestern Medical Center, Department of Pediatrics, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9063. E-mail: firstname.lastname@example.org.
Objectives: The aim of the study was to compare the prevalence of vitamin D deficiency in obese and non-overweight children in North Texas, to examine relationships between dietary habits and 25-hydroxyvitamin D [25(OH)D] level in obese children, and to examine the relationship between 25(OH)D level and markers of abnormal glucose metabolism and blood pressure.
Patients and Methods: Using a cross-sectional design, systolic and diastolic blood pressure, dietary information, serum 25(OH)D, fasting glucose and insulin, 2-h glucose from oral glucose tolerance test, hemoglobin A1c, and homeostasis model assessment of insulin resistance were recorded for 411 obese subjects (6â€“16 yr old) at an obesity referral clinic. 25(OH)D was also obtained from 87 control non-overweight subjects (6â€“16 yr old).
Results: Ninety-two percent of obese subjects had a 25(OH)D level below 75 nmol/liter, and 50% were below 50 nmol/liter. Among non-overweight subjects, these frequencies were 68 and 22%, respectively (both P < 0.01 compared with obese subjects). 25(OH)D was negatively associated with soda intake (P < 0.001), juice intake (P = 0.009), and skipping breakfast (P < 0.001). 25(OH)D was negatively correlated with homeostasis model assessment of insulin resistance (r = âˆ’0.19; P = 0.001) and 2-h glucose (r = âˆ’0.12; P = 0.04) after adjustment for body mass index and age but was not correlated with hemoglobin A1c, systolic blood pressure Z score, or diastolic blood pressure Z score.
Conclusions: Vitamin D deficiency is common in children in this southern United States location and is significantly more prevalent in obese children. Lower 25(OH)D level is associated with risk factors for type 2 diabetes in obese children.
- Body mass index
- confidence interval
- diastolic blood pressure
- hemoglobin A1c
- homeostasis model assessment of insulin resistance
- oral glucose tolerance test
- 25-hydroxyvitamin D
- systolic blood pressure.
- Received May 16, 2011.
- Accepted October 6, 2011.
- Copyright Â© 2012 by The Endocrine Society
Responses to this article
- Silva A. Arslanian and
- Javier de las Heras and Kumaravel Rajakumar
The importance of adjusting for abdominal adiposity when examining the relationship between 25-hydroxyvitamin D levels and glucose homeostasis. The Journal of Clinical Endocrinology & Metabolism published online February 25, 2012