Happy Face Stomach PaintingIt appears that the developing gut bacteria in newborns is even more important than previously thought. Antibiotics and other chemical toxins destroy gut bacteria. As the microbiome develops in humans it also determines how our metabolism gets established and our digestive patterns for life are formed according to a NYU research team and published in Cell.

Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity.

We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects.

In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations.

For further reading:

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences
Cox, Laura M; Yamanishi, Shingo; Sohn, Jiho; Alekseyenko, Alexander V; Leung, Jacqueline M; Cho, Ilseung; Kim, Sungheon G; Li, Huilin; Gao, Zhan; Mahana, Douglas; Zarate Rodriguez, Jorge G; Rogers, Arlin B; Robine, Nicolas; Loke, P’ng; Blaser, Martin J
2014 Aug;158(4):705-721, Cell
— id: 1132022, year: 2014, vol: 158, page: 705, stat: Journal Article,

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