Buckwheat Exerts Protective Effect, Reduces Oxidative Stress Risk Factors.
Most studies conducted to date, have investigated the effect of various buckwheat extracts or individual molecular components on cell lines and animal models, with relatively few studies being performed on humans. 
The present study provided a valuable contribution in this context, particularly with regard to investigating the potential anti-inflammatory effect. Of relevance, it was possible to examine the above-mentioned parameters, after the consumption of the buckwheat-enriched wheat as the staple carbohydrate source in the diet.
The effects were then compared with those obtained after the consumption of modern wheat alone on the same population of Italian individuals, traditionally accustomed to wheat as a staple carbohydrate source. The results showed a positively impact on CVD risk by downregulating several key parameters associated with the disease.
In conclusion, a replacement diet with buckwheat-enriched products impacted positively by down-regulating several key parameters associated with CVD risk, including total cholesterol, LDL cholesterol, blood glucose, insulin, and the HOMA index.
No improvements in the inflammatory profile were observed in the present studies that were specifically related to the consumption of buckwheat products. Additional human research is necessary to further investigate the possible beneficial effect of this pseudo-cereal.
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Citation: Sofi F, Ghiselli L, Dinu M, Whittaker A, Pagliai G, et al. (2016) Consumption of Buckwheat Products and Cardiovascular Risk Profile: A Randomized, Single-Blinded Crossover Trial. J Nutr Food Sci 6:501. doi:10.4172/2155-9600.1000501