10 Nutrigenomics Breakthroughs

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‘You are what you eat’ is a phrase that might strike fear into your heart depending on what is in your mouth at the time! 

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Tart Cherry Juice Lowers Blood Pressure

10 Nutrigenomics Breakthroughs from ten years of research (2008-2018)

By Aidan Connolly

If our genes are the blueprint that defines who we are, it is how they express themselves in the presence of nutrition, to produce proteins. ‘Gene expression’ patterns caused by food, also called nutrigenomics, tell us if we are sick, how we will react if we get sick, and if what we are eating or doing can make us better.

That’s the basic idea. We can see this play out in the way thoroughbred horses or zoo animals are fed. They’re given the highest quality food, it’s measured to the ounce and fed to the animals at specific times. There is a great deal about nutrigenomic data that has been gleaned from animal studies.

The Alltech Nutrigenomics Center has been studying animal nutrition’s impact on gene expression. This allowed scientists to determine in hours what outcomes to expect from feeding specific foods, feeds and dietary supplements to animals without waiting months or even years for results typical in farm trials.

Over the past ten years, nutrigenomics has now been used to

a)    Understand how specific foods change gene expression

b)    Quickly screen for new nutrients with similar benefits

c)     Predict responses to nutrients or foods.

What are the top 10 Highlights in Nutrigenomic research? Read more of Aidan Connolly’s article and be amazed at how much more we know now that we did ten years earlier.

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Carb-Restricted Diet Battles Fatty Liver Disease

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The metabolism of dangerous hepatic lipids was “strongly linked” to rapid increases in B vitamins and the bacteria that produce folic acid.

 “We found that the diet, independently of weight-loss, induced rapid and dramatic reductions of liver fat and other cardiometabolic risk factors, and revealed hitherto unknown underlying molecular mechanisms.”

Tart Cherry Juice Lowers Blood Pressure

Study Shows How A Carb-restricted Diet Battles Fatty Liver Disease

KTH The Royal Institute of Technology

New details about how a carbohydrate-restricted diet improves metabolism were revealed in a study published today, which could lead to improved treatments for non-alcoholic fatty liver disease (NAFLD).

A research team in Sweden examined  the effects of reduced carbohydrate consumption – without an accompanying reduction in calorie intake – by putting 10 subjects with obesity and high liver fat on a two-week diet. The study, which involved KTH Royal Institute of Technology’s SciLifeLab research center, combined clinical and big data analysis to determine the subsequent changes in metabolism and gut bacteria.

By doing so, they identified why the subjects showed “rapid and dramatic” reductions of liver fat and other cardiometabolic risk factors, along with marked decreases in synthesis of hepatic fat. Published today in Cell Metabolism, the work was authored by researchers from KTH, University of Gothenburg and other international collaborators.

Adil Mardinoglu, a systems biology researcher at KTH, says that the subjects were restricted to an isocaloric, low-carbohydrate diet with increased protein content. The researchers found that the metabolism of dangerous hepatic lipids was “strongly linked” to rapid increases in B vitamins and the bacteria that produce folic acid.

This benefit was coupled by a reduction in the expression of genes that are involved in fatty acid synthesis, and an increase in the expression of genes involved in folate-mediated one-carbon metabolism and fatty acid oxidation.

“A carbohydrate-restricted dietary intervention such as the one we used can be an efficient treatment strategy for a severe health problem, as medical science continues the development of new drugs,” Mardinoglu says.

The study relied upon a combination of systems medicine and advanced clinical studies, with close interaction between experts in systems medicine, basic scientists, nutritionists and clinicians. Combining forces enabled the team to apply a “multi-omics” approach, which means integrating multiple data sets from the body’s omes (genome, proteome, transcriptome, etc.) to identify biomarkers.

“We’ve moved from an era where scientists could work individually and command – in one laboratory – everything they needed, to a world that’s much more interactive,” Mardinoglu says.

Lead author Jan Boren, a professor at University of Gothenburg, says: “We found that the diet, independently of weight-loss, induced rapid and dramatic reductions of liver fat and other cardiometabolic risk factors, and revealed hitherto unknown underlying molecular mechanisms.

“It’s important, however, to clarify that diets are complicated and that one type of diet does not fit everyone. For example, subjects with hypercholesterolemia should be careful.”

Liver fat is the earliest abnormality in the pathogenesis of both NAFLD and alcoholic fatty liver disease (AFLD) due to metabolic risk factors associated with insulin resistance and metabolic syndrome in the presence or absence of alcohol consumption.

Therefore, the strategies the research team identified could be used also for the treatment of AFLD patients, Boren says.

https://doi.org/10.1016/j.cmet.2018.01.005

 

Plant-Based Foods Could Save A Country Billions

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“Our research demonstrates that increasing plant-based eating is cost-effective, reduces economic costs, such as hospital admissions and doctors’ bills, as well as increasing the number of healthy years people live, and enabling them to continue having an active life,”

Lieven Annemans

Professor of Health Economics at Ghent University,

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Eating Our Landscape Could Prove To Be Profitable as Well as Healthy

14 February 2018 Ghent University

Billions of euro could be saved from a country’s annual health bill if more people can be persuaded to follow a plant-based diet, according to new research published in the Journal of Nutrition. Also society overall will benefit due to less absenteeism from work.

The study looked at the health and economic consequences of two plant-based eating patterns, a diet with a daily portion of soya foods and a Mediterranean-style diet.

The study suggests the British government could reduce its healthcare and societal costs over the next 20 years by £5.21 billion if just 10% of the UK population would emphasize plant-based foods in their diet. Cost savings could be as high as £7.54 billion if 10% of the UK population could be encouraged to incorporate soya products in their daily diet.

“Our research demonstrates that increasing plant-based eating is cost-effective, reduces economic costs, such as hospital admissions and doctors’ bills, as well as increasing the number of healthy years people live, and enabling them to continue having an active life,” said Lieven Annemans, professor of health economics at Ghent University, and the lead author of the paper. “Our study has the potential to contribute to the way healthy eating is promoted,” he added.

There are different approaches to plant-based eating, from Mediterranean-type diets through to vegetarian and veganism. Plant-based eating is in line with the latest government dietary guidelines, the Eatwell Guide. In other words, plant-based eating does not have to exclude all animal products, but places plant-based foods such as soya, fruits, vegetables, wholegrains, nuts, seeds and vegetable oils at the core of the diet.

The researchers carried out an extensive review of the scientific literature and concluded that both plant-based and soya eating patterns reduce the risk of diseases such as diabetes, cardiovascular disease, stroke and certain cancers. Diets containing soya demonstrated the most favorable health effects from the two evaluated plant-based food patterns.

The researchers calculated the impact of these plant-based food patterns on ‘quality adjusted life years’ (QALYs), which estimate the number of expected years of good health. To calculate disease costs, a societal perspective was taken, including direct and indirect costs. Direct costs are those directly associated with the disease or related conditions including costs related to diagnosis and treatment. Indirect costs include employment related elements such as absenteeism, and productivity loss due to sickness.

For the UK, a diet containing soya is estimated to yield 159 QALYs and 100 QALYs per 1,000 women and men, respectively. Similarly, adherence to a plant-based Mediterranean-type diet also results in living longer in good health and cost-savings to society.

Professor Ian Rowland, professor in nutrition from Reading University, supported the findings of the new study and commented: “Emphasizing plant-based foods in your diet can help to improve nutrition and meet current dietary recommendations. More plant-based eating helps against a variety of diseases which many people are currently confronted with. In addition to the personal health benefits, it can also help reduce society’s healthcare costs.”

This study provides yet more reasons to eat more plant-based foods and is in line with the UK ‘Eatwell guide’ which champions plant-based foods for good health and sustainability. It follows a report published by the Sustainable Food Trust in November – The Hidden Cost Of UK Food – which found that poor diets add 37p of healthcare costs to every £1 spent on food.

https://www.sciencedirect.com/science/article/pii/S0899900717302861

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Six Questions About Cellphone Radiation Risk and Your Health

Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure

Cellphone Radiation and Your Health

While many communities are just beginning to deal with the impacts of radiation in our built environment, like smart meter technology, LED street light bulb replacement, dark skies, ordinances from light pollution, In Europe many of these laws are already on the books.

.As other communities begin to grapple with radiation issues from our built environment like smart meters, LED streetlight conversions and dark skies ordinances, the city of Berkeley, California won a major decision in a federal appeals court, allowing the city to go forward with its ordinance requiring cellphone retailers to provide consumers with information about safe cellphone use.

The court denied a request by the the mobile phone industry’s lobby, CTIA-The Wireless Association, which had fought the city’s attempts to educate its citizens.

Meanwhile the Berkeley’s ordinance, in effect since March 2016, requires the following notification:

To assure safety, the Federal Government requires that cellphones meet radiofrequency (RF) exposure guidelines. If you carry or use your phone in a pants or shirt pocket or tucked into a bra when the phone is ON and connected to a wireless network, you may exceed the federal guidelines for exposure to RF radiation. Refer to the instructions in your phone or user manual for information about how to use your phone safely.

Last month, under court order, the California Department of Public Health released draft guidelines on cellphone safety that outlined the health risks from cellphone radiation. For an in depth history, check out The Environmental Working Group. Assess your risks, look at the science, and follow other trends impacting public policy and our health and well being.

Parents For Safe Technology have been reporting the legislative track on this issue in addition to many other technology and public safety related issues. France is imposing a total ban of cell phones in school. What should we know to be informed? Please see EWG’s Cellphone Radiation FAQs.

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The Nutrition Science Behind Oranges

Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure
Tart Cherry Juice Lowers Blood Pressure

The Science Behind Oranges

Eating fresh, local, organic food is your best option. When it comes to oranges, forget about ascorbic acid. There’s loads of science behind the juice, the aroma and the peel.

The many medicinal properties of oranges makes it worth turning your foodie filter toward fresh oranges. As  you careen through your culinary landscape, knowing which foods offer you the biggest nutritional bang is more important today than ever before.

First it was oranges. Sweet oranges were mentioned in Chinese literature in 314 BC.[2] As of 1987, orange trees were found to be the most cultivated fruit tree in the world.[5]  As of 2012, sweet oranges accounted for approximately 70% of citrus production.[7]

The beginning of the citrus industry in the U.S. started in Riverside, CA. Eliza Tibbits planted the first navel orange tree. It came from Brazil and still grows today. At the turn of the last century, Riverside had the highest per capita income of any city in the U.S. based on the explosion of the citrus industry.

Riverside orange juice is uncommonly sweet. A combination of factors including excellent soil, abundant local water and a community that understands the value of real food, is reinvigorating local agriculture with it’s Grow Riverside Conference.

At the same time, the Asian Citrus Psyllid threatens citrus as we know it. It’s already destroyed 70% of Florida’s citrus industry. Find out what to look for on your citrus trees. Once infected, it takes about 5 years for the tree to die. In the meantime, the fruit quality drops dramatically.

Now might be a good time to start paying attention to fresh citrus. Oranges are definitely worth putting on your own favorite super foods list. Find out why.

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