How Your Gut Microbiota Affects Intestinal Integrity

ProbioticsBacteria in the gut help the body to digest food, and stimulate the immune system. A PhD project at the National Food Institute, Technical University of Denmark, examines whether modulations of the gut bacterial composition affect intestinal integrity, i.e. the ability of the body to maintain a well-regulated barrier function that hinders bacteria from entering the body unintentionally.

The human gut contains more than 100 trillion bacteria, which help the body digest food, produce vitamins protect against disease-provoking bacteria in food, and stimulate the immune system.

All these bacteria are separated from the rest of the body by the intestinal wall, which functions as a selective barrier aimed at allowing only useful substances to pass and be absorbed in the body.

Ellen Gerd Christensen, PhD student at the National Food Institute, has examined whether a change in gut bacterial composition affects intestinal integrity. Results show that increased intake of whole-grain wheat increases the number of bifidobacteria, which are considered beneficial for human health. In addition, the study indicated that bifidobacteria may have a negative effect on intestinal integrity. However, subsequent animal testing in rats showed no changes in intestinal integrity after dosing with live bifidobacteria.

Antibiotics also have an effect
In addition, experiments in rats showed that administration of antibiotics, which cause immense changes in the bacterial gut composition, have an effect on intestinal integrity in either a positive or negative direction, depending on the specific antibiotics.

The findings of this PhD project can be used to clarify how changes in the composition of the natural gut bacterial community may affect intestinal function and permeability.

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Read Ellen Gerd Christensen’s PhD thesis:

Industrial Strength Six Sigma Health Care


Industrial Strength Healthcare

13 August 2014 Inderscience

Doctor Patient ConsultingI don’t know about you, but I’ve often been dismayed with how inefficient and time wasting our medical delivery system is. Maybe we should be taking a look at what research is telling us.

By adapting the “Lean Six Sigma” principle of manufacturing to rural hospitals, Indian researchers suggest that patient queues might be shortened by 91 percent while consultation time could be reduced to about a third of the time. Details of the approach are reported in the International Journal of Healthcare Technology and Management.

The Six Sigma approach to manufacturing is a set of techniques and tools developed by electronics company Motorola in 1986 to improve its development and manufacturing processes. It improves quality and efficiency by identifying and treating the causes of errors and defects and minimizing variability in manufacturing and in the associated business processes. It is widely used in many disparate areas of industry. Lean Six Sigma as the name suggests combines these efficiency principles with the concept of “lean manufacturing” in which expenditure that does not add value to the end product and consumer and therefore the company’s profits is minimized if not eradicated.

Now, Shreeranga Bhat of St Joseph Engineering College, in Karnataka, India and colleagues have applied the Lean Six Sigma principles, define, measure, analyze, improve and control process, to a rural Indian hospital to improve quality and care for patients.

Their work demonstrates that ergonomic improvements in the healthcare environment as well as improvements to the handling of patient records and the progression of patients from the hospital entrance to the treatment room to their ultimate discharge with relevant prescribed medication and advice. The approach was also able to uncover problems with staff morale, training and administrative issues.

The successful implementation of this approach in a local rural hospital by the team was an “eye opener” for management, they say and “ultimately brought about a cultural change within the organization by involving everyone in the push towards excellence.”

Given the large numbers of people that might enter a rural hospital in India each year and the potential for waste in the face of limited resources, the adoption of a Lean Six Sigma approach that has been successfully applied in manufacturing industries could be a significant step towards improved healthcare for rural communities in the developing world.

Low Education, Smoking And Increased Stroke Risk


Low education, smoking, high blood pressure may lead to increased stroke risk

Risk Ahead SignAdults smokers with limited education face a greater risk of stroke than those with a higher education, according to new research in the American Heart Association’s journal Stroke.

The combination of smoking and high blood pressure increased stroke risk the most, confirming earlier findings in numerous studies.

In a multicenter Danish study, researchers defined lower education as grade school or lower secondary school (maximum of 10 years) education.

“We found it is worse being a current smoker with lower education than a current smoker with a higher education,” said Helene Nordahl, Ph.D., M.S.C., study lead author and researcher at the Department of Public Health at the University of Copenhagen in Denmark. “Targeted interventions aimed at reducing smoking and high blood pressure in lower socioeconomic groups would yield a greater reduction in stroke than targeting the same behaviors in higher socioeconomic groups.”

Researchers divided 68,643 adults (30-70 years old) into low, medium and high education levels and assessed smoking and high blood pressure levels. They found:

  • Sixteen percent of men and 11 percent of women were at high-risk of stroke due to low education level, smoking and high blood pressure.
  • Men were more at risk of stroke than women, and the risk of stroke increased with age.
  • Ten percent of the high-risk men and 9 percent of the high-risk women had an ischemic stroke during the study’s 14-year follow-up.
  • Smokers with low education had a greater risk of stroke than smokers with high education regardless of their blood pressure.

Hypertension Collage“Universal interventions such as legislation or taxation could also have a strong effect on stroke in the most disadvantaged,” Nordahl said. “We need to challenge disparities in unhealthy behaviors, particularly smoking.”

Researchers weren’t able to consider differences associated with ethnicity because 98 percent of the participants were Danes.

“The distribution of stroke risk factors may vary across various contexts and study populations,” Nordahl said. “However, since the most disadvantaged groups are often exposed to a wide number of stroke risk factors, it seems plausible that these people are at higher risk of stroke not only in Denmark, but also in other industrialized countries.”

The GMO Fight Ripples Down the Food Chain

You know the GMO labeling movement is gaining traction when the Wall Street Journal chooses to warn the investors of pitfalls ahead.

Updated Aug. 7, 2014 10:38 p.m. ET

Genetically modified foods, or GMOs, are in an estimated 80% of packaged foods. Some companies, like Ben & Jerry’s, are trying to go GMO-free. But it’s not easy. An animated explainer.

Two years ago, Ben & Jerry’s Homemade Inc. initiated a plan to eliminate genetically modified ingredients from its ice cream, an effort to address a nascent consumer backlash and to fulfill its own environmental goals.

This fall, nearly a year behind schedule, it expects to finish phase one, affecting its flavorful “chunks and swirls” like cookie dough and caramel. The only part left to convert: the milk that makes ice cream itself. Thanks to the complexities of sourcing milk deemed free of genetically modified material, that could take five to 10 more years.

“There’s a lot more that goes into it than people realize,” said Rob Michalak, Ben & Jerry’s director of social mission.

Two decades after the first genetically engineered seeds were sold commercially in the U.S., genetically modified organisms—the crops grown from such seeds—are the norm in the American diet, used to make ingredients in about 80% of packaged food, according to industry estimates. (Take a quiz about GMOs.)

Now an intensifying campaign, spearheaded by consumer and environmental advocacy groups like Green America, is causing a small but growing number of mainstream food makers to jettison genetically modified organisms, or GMOs. In addition to Ben & Jerry’s, a subsidiary of Unilever ULVR.LN +0.38%PLC, General Mills Inc. GIS +0.46% this year started selling its original flavor Cheerios without GMOs. Post Holdings Inc. took the GMOs out of Grape-Nuts.Boulder Brands Inc. BDBD -0.30% ‘s Smart Balance has converted to non-GMO for its line of margarine and other spreads. Chipotle Mexican Grill Inc. CMG +0.89% is switching to non-GMO corn tortillas.

“Non-GMO” is one of the fastest-growing label trends on U.S. food packages, with sales of such items growing 28% last year to about $3 billion, according to market-research firm Nielsen. In a poll of nearly 1,200 U.S. consumers for The Wall Street Journal, Nielsen found that 61% of consumers had heard of GMOs and nearly half of those people said they avoid eating them. The biggest reason was because it “doesn’t sound like something I should eat.”

Grass roots campaigns in several states are pushing for mandatory labeling of foods with GMOs—something most food companies staunchly oppose. In May, Vermont adopted the first state law requiring companies to label GMO foods, starting in 2016.

The anti-GMO backlash reflects the deep skepticism that has taken root among many U.S. consumers toward the food industry and, in particular, its use of technology. Similar criticism has roiled other food ingredients including artificial sweeteners and finely textured beef, the treated meat product that critics dubbed “pink slime.” The Web and social media have enabled consumer suspicions in such matters to coalesce into powerful movements that are forcing companies to respond.

Critics of GMOs—which have combined genes from different organisms to make some staple crops more durable—say there haven’t been enough independent studies on the long-term health and environmental consequences of what they dub as “Frankenfood.” They cite a handful of studies outside the U.S. that found toxic effects on animals fed genetically modified crops, and point out that 64 nations, including the European Union countries and China, require labeling of GMO products.

“If it turns out that after doing the studies, the scientific evidence shows GMOs are OK, I will change my mind,” said Alisa Gravitz, a board member of the Non-GMO Project and chief executive of Green America. “But until then, why infect our entire food supply with this, when the early studies, the bona fide, peer-reviewed ones, throw up some red flags?”

For its part, the food industry says those studies are inconclusive and that none has shown any link to harm to humans. Proponents also point out that GMO crops used in the U.S.—which also include alfalfa, cotton, papaya and squash—have been approved by the Food and Drug Administration, which doesn’t mandate labeling food that contains them. And even though the European Union requires labeling in member countries, it has approved many GMO foods as safe for consumption.

The debate aside, how companies like General Mills and Ben & Jerry’s fare in dropping GMOs will offer a guide to others that are considering it. So far, the process has proved expensive, complex and politically dicey. For Ben & Jerry’s, the premium for non-GMO ingredients ranged from 5% to 20%, reflecting how deeply rooted the technology is in the U.S. food chain. Ben & Jerry’s says it plans to eat the costs rather than pass them on to customers.

But the forerunners are also encouraging farmers and ingredient manufacturers to increase the supply of non-GMO items, which could make it easier for food makers to follow.

Certainly, the stakes are large for companies like Monsanto Co. MON +0.45% andDuPont Co. DD +0.82% , which sell genetically engineered seeds to give crops traits like the ability to repel insects or resist weed killers. Today, more than 90% of corn, canola, soybean and sugar beet crops in the U.S. are genetically modified. Most of the produce Americans consume directly isn’t GMO, but the crops are used to produce common ingredients like corn syrup, soy lecithin and more than half of the sugar consumed in the U.S.—plus the feed consumed by most of the nation’s livestock.

In a statement, a spokeswoman for Monsanto said the company was confident about the safety of its seeds based on an “extensive body of rigorous testing” by company and independent researchers. DuPont pointed out the technology was backed by “regulatory agencies and scientific organizations around the world.” The switch to GMO, proponents say, has led to higher crop yields and lower food costs.

When a big brand announces plans to drop GMOs, it stirs the debate further. GMO backers criticized General Mills for its change to Cheerios, saying it gave credence to misperceptions of the technology. Anti-GMO groups quickly started calling on General Mills to drop them from its Honey Nut Cheerios, too. The company said that changing the ingredients of its other cereals would be too difficult, but that GMO products are safe, adding that it offered the non-GMO variety to give consumers more options.

Non-GMO chocolate chunks used in some Ben & Jerry’s ice cream. Cheryl Senter for The Wall Street Journal

Ben & Jerry’s, which ranks fifth among U.S. ice cream brands by sales, says it doesn’t consider GMOs unsafe to humans either, but has always positioned itself as an environmentally friendly, socially progressive brand. Executives long wanted to drop GMOs, which they feel are part of industrialized, chemical-intensive agriculture that the company opposes, said Mr. Michalak, the social mission director. But the company didn’t start discussing converting its flavors with suppliers until 2012.

That year, anti-GMO advocates got on the California ballot Proposition 37, a measure requiring GMO labeling similar to the one that later passed in Vermont. Food and agriculture companies poured more than $46 million into advertising to fight the measure, saying it would confuse consumers and raise food costs. The measure narrowly failed to pass, but it galvanized GMO opponents and put the industry on notice.

Ben & Jerry’s didn’t get directly involved in the California fight. But the battle “catalyzed the movement for us,” said Cheryl Pinto, Ben & Jerry’s ingredient sourcing manager. “When all the non-GMO hoopla hit the fan, we realized we better accelerate our conversion.”

Aside from the milk, Ben & Jerry’s said most ice cream ingredients were already non-GMO. Still, the company needed to check with suppliers and rigorously investigate all 110 ingredients it uses to make ice cream. Among the surprises: finding out a product couldn’t be considered non-GMO if the supplier dusted the pan with cornstarch before baking. The supplier had to switch to rice starch.

“Our suppliers generally had to negotiate all the way down the supply chain to get to the farmer,” Ms. Pinto said.

At the farm level, companies confront a chicken-or-egg-type conundrum. Food makers are hesitant to commit to dropping GMOs until they are sure they can find sufficient sources of non-GMO crops. But farmers are reluctant to switch seeds unless they know there will be guaranteed demand for non-GMO crops at a premium price.

Mercaris, a market data researcher, said prices last year for non-GMO corn averaged 51 cents per bushel higher than those for regular, GMO corn. That is a significant difference for farmers when the national average corn price was between $4 to $4.50. But some farmers also worry that dropping GMO seeds could lower their yields, meaning fewer bushels per acre.

Ben & Jerry’s paid an average of 11% more for each ingredient that changed to a non-GMO version. In some cases that also included the higher cost of sourcing ingredients from Fair Trade suppliers—those certified as paying fair prices to producers in developing countries—which it did simultaneously.

The company says it can’t quantify how much it spent on the non-GMO conversion in total. “It was really expensive,” Ms. Pinto said. “Surcharges came in from transportation. Instead of buying beet sugar from down the road, you’re buying cane sugar from much farther away.” The conversion also required time and money to design new labeling and marketing and carry out legal reviews, she said.

For its Chubby Hubby ice cream, Ben & Jerry’s had to change peanut butter pretzel suppliers because ConAgra Foods Inc., which bought the company that supplied the pretzels, was unwilling or unable to adhere to the non-GMO and Fair Trade requirements, according to people familiar with the situation. The change in suppliers also caused a shift from peanut butter-filled pretzels to peanut butter-coated ones, prompting some consumers to complain. ConAgra declined to comment.

To some degree, Ben & Jerry’s process was simple relative to what some companies put themselves through. Unlike with organic foods—which also can’t contain GMOs but must follow additional restrictions—the government sets no standard for what qualifies as “non-GMO.” Companies seeking some authoritative imprimatur must go to third-party certifiers, usually the Non-GMO Project, a nonprofit group founded by natural foods retailers. It vets applicants with an almost religious exactitude.

To gain its certification, Enjoy Life Foods LLC, a small Schiller Park, Ill.-based company that makes gluten- and allergen-free snacks, traced its honey to the hive. “We had to go to our honey suppliers, who went to the bee keepers, who had to actually determine how far the bees could fly to make sure they weren’t cross-pollinating at any GMO fields,” said Joel Warady, its chief sales and marketing officer.

He said the company thought it was done a year before it actually was, because Non-GMO Project kept coming with questions, including how far their bees flew. “I was like, ‘Are you serious? I don’t know,’ ” said Mr. Warady. ” ‘I didn’t talk to the bees.’ “

The Non-GMO Project, which has verified more than 17,000 products, says such lengths are necessary to ensure the bees aren’t feeding on nectar or pollen from GMO crops. Thus, the organization requires a four-mile radius from the bee hives be clear of GMO fields.

“Consumers don’t know how difficult it is, but they also don’t care how difficult it is,” said Mr. Warady. “They say, ‘I want the food all natural. I want it to be non-GMO. I want it to taste great. And by the way, I don’t want to pay any more for that. Figure it out.’ ” EnjoyLife Foods 3065.TO +0.81% doesn’t explicitly pass on the added costs, but its food is already priced at a premium to mainstream brands. For its part, Ben & Jerry’s didn’t seek Non-GMO Project certification, citing the complexity, but does use an auditor. “For us, our size and our scale, we had to be” realistic about where to start, Ms. Pinto said.

The number of big companies that have announced plans to drop GMOs is still small. Big industry groups like the Grocery Manufacturers Association say the trend is baseless, but they admit it is growing. They continue to lobby against GMO labeling and tout the benefits of the technology.

Still, industry executives say many of those companies are asking suppliers to develop non-GMO options so that they can be ready in case label mandates spread, which the companies fear could hurt products containing GMOs. Brian Sethness, senior account executive at Sethness Products Co., which supplies caramel coloring to major food and beverage companies, said the company is receiving more inquiries about non-GMO products than ever before. “Most haven’t pulled the trigger yet though, they just want to know what’s out there,” he said.

For Ben & Jerry’s, the biggest hurdle is milk. The vast majority of the feed given to dairy cows in the U.S. is made with GMO corn, soybeans and alfalfa. That makes it difficult to find non-GMO milk in quantities large enough for Ben & Jerry’s, so the company hasn’t committed to doing it. Labeling laws like the one passed in Vermont don’t apply to meat or dairy derived from animals that consumed GMO animal feed, buying Ben & Jerry’s more time. “We are having conversations with multiple stakeholders throughout the entire supply chain,” Mr. Michalak said. “It’s a slow process.”

Write to Annie Gasparro at

Tree Nuts Improve Glycemic Control For Individuals With Type 2 Diabetes

Mixed NutsIn a study published July 30, 2014 DOI: 10.1371/journal.pone.0103376 indicates the wisdom of eating more nuts. In fact, eating more nuts is just the ticket. You don’t even have to take me out the ballpark. The jury is in so go nuts.

The ability of tree nuts to improve glycemic control may relate to a carbohydrate displacement mechanism by which tree nuts reduce the glycemic load of the diet by displacing high glycemic-index carbohydrates. And they taste better than hi fructose carb snacks. read more:  Effect of Tree Nuts on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Dietary Trials

Tree nuts are the perfect workplace snack. Not only do they taste good, they also help reduce work-related stress, a risk factor for type 2 diabetes.

Workplace stress can have a range of adverse effects on health with an increased risk of cardio-vascular diseases in the first line.

Risk of diabetes about 45 percent higher.

Individuals who are under a high level of pressure at work and at the same time perceive little control over the activities they perform face an about 45 percent higher risk of developing type 2 diabetes than those who are subjected to less stress at their workplace.

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